On this page
- Antiulcer agent (histamine H2-receptor antagonist)
- Prophylaxis of acid pulmonary aspiration syndrome in anaesthesia:
- in patients with a full stomach (emergency caesarean section, etc.)
- when a difficult intubation is expected
Forms and strengths
- 200 mg effervescent tablet
Also comes 800 mg effervescent tablet.
Dosage and duration
- Adult: 200 to 400 mg single dose, if possible one hour before anaesthetic induction
Contra-indications, adverse effects, precautions
- May cause: diarrhoea, headache, dizziness, skin rash, fever.
- Do not administer with an antacid (aluminium hydroxide, etc.).
- Effervescent cimetidine can be replaced by effervescent ranitidine, another H2-receptor antagonist, as a single dose of 150 mg.
- The onset of acid inhibition with cimetidine non-effervescent tablets (200 mg, 400 mg and 800 mg film coated tablets) or ranitidine non-effervescent tablets (150 mg and 300 mg film coated tablets) occurs 30 minutes after administration. The effervescent tablets containing sodium citrate have a more rapid onset of action, and can thus be used for emergency surgery.
- Omeprazole, another antiulcer agent (proton pump inhibitor), is not compatible with emergency situations as it must be administered at least 4 hours before surgery.
- Cimetidine in film coated tablets is also used in the treatment of gastro-oesophageal reflux and peptic ulcer. Use by preference ranitidine or omeprazole for these indications.
- Below 25 °C