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- Intermediate-acting steroidal anti-inflammatory drug (corticosteroid)
- Symptomatic treatment of allergic and inflammatory diseases or reactions
Forms and strengths
- 5 mg tablet and 5 mg soluble tablet
Dosage and duration
- Dosage varies according to indication, symptoms severity, clinical response and patient's tolerance. In the event of treatment longer than 10 days, a high initial dose should be reduced as quickly as possible to the lowest effective dose.
- Child and adult: 0.5 to 2 mg/kg once daily in the morning or in 2 divided doses (max. 80 mg daily)
- Duration varies according to indication. In the event of treatment longer than 3 weeks, decrease doses gradually to avoid adrenal suppression.
Contra-indications, adverse effects, precautions
- In case of systemic infection, only administer if patient is under antimicrobial treatment.
- Do not administer to patients with active peptic ulcer (except if ulcer under treatment).
- May cause (if prolonged treatment with high doses): adrenal suppression, muscle atrophy, growth retardation, increased susceptibility to infections, sodium and water retention (oedema and hypertension), osteoporosis, hypokalaemia, digitalis toxicity due to potassium loss in patients taking digitalis glycosides.
- Pregnancy: no contra-indication
- Breast-feeding: no contra-indication; use the lowest effective dose; for treatment longer than 7 days with doses higher than 40 mg daily, take tablets just after a feed and wait 4 hours before the next feed if possible.
- Take with food.
- Prednisolone is also used for preventing inflammatory reaction triggered by certain antiparasitic treatment (e.g. trichinellosis, african trypanosomiasis).
- 5 mg of prednisolone or prednisone has the same anti-inflammatory activity as 0.75 mg of dexamethasone and 20 mg of hydrocortisone.
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