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- Antiretroviral, HIV protease inhibitor
- HIV infection, in combination with ritonavir (booster) and other antiretrovirals
Forms and strengths
- 200 mg capsule
- 300 mg atazanavir/100 mg ritonavir tablet
- Child 10 to < 25 kg: one 200 mg capsule once daily (+ 100 mg ritonavir once daily)
- Child ≥ 25 kg and adult: one 300 mg/100 mg tablet once daily
- Depending on the efficacy and tolerance of atazanavir and ritonavir.
Contra-indications, adverse effects, precautions
- Do not administer to patients with severe hepatic impairment.
- Administer with caution and monitor use in patients with haemophilia (increased bleeding) or mild to moderate hepatic impairment.
- May cause:
- jaundice, gastrointestinal disturbances, headache, insomnia, fatigue, peripheral neuropathy, asymptomatic hyperbilirubinaemia, cholelithiasis, urolithiasis, conduction disorders, hyperglycaemia, hyperlipidaemia, lipodystrophy;
- skin rash sometimes severe, hepatic disorders; in this event, stop treatment immediately.
- Do not combine with rifampicin or omeprazole (decreased plasma concentrations of atazanavir):
- replace rifampicin with rifabutin;
- if omeprazole is necessary, do not exceed 20 mg daily and take each drug 12 hours apart.
- Administer with caution and monitor combination with drugs that prolong the QT interval (amiodarone, co-artemether, mefloquine, quinine, haloperidol, etc.).
- Do not administer simultaneously with antacids containing aluminium or magnesium hydroxide. Take 2 hours apart.
- Atazanavir in combination with ritonavir reduces the efficacy of implants and oral contraceptives: use injectable medroxyprogesterone or an intrauterine device or an oral contraceptive containing at least 30 micrograms of ethinylestradiol per tablet.
- Pregnancy: no contra-indication; monitor bilirubin levels and/or signs of jaundice in neonates.
- Take with meals together with ritonavir.
- Do not open the capsules.
- Also comes in 100 mg, 150 mg and 300 mg capsules, not in combination with ritonavir.
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