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    Prescription under medical supervision


    Therapeutic action

    • Antiretroviral, HIV protease inhibitor


    • HIV infection, in combination with ritonavir (booster) and other antiretrovirals

    Forms and strengths

    • 200 mg capsule
    • 300 mg atazanavir/100 mg ritonavir tablet


    • Child 20 to < 25 kg: one 200 mg capsule once daily (+ 100 mg ritonavir once daily)
    • Child ≥ 25 kg and adult: one 300 mg/100 mg tablet once daily


    • The duration of treatment depends on the efficacy and tolerance of atazanavir and ritonavir.

    Contra-indications, adverse effects, precautions

    • Do not administer to patients with moderate and severe hepatic impairment or in combination with rifampicin.
    • Administer with caution and monitor use in patients with haemophilia (increased bleeding) or in patients with mild hepatic impairment.
    • May cause:
      • jaundice, gastrointestinal disturbances, headache, insomnia, fatigue, peripheral neuropathy, asymptomatic hyperbilirubinaemia, cholelithiasis, urolithiasis, conduction disorders, hyperglycaemia, lipodystrophy;
      • skin rash sometimes severe, hepatic disorders; in this event, stop treatment immediately.
    • Administer with caution and monitor combination with drugs that prolong the QT interval (amiodarone, co-artemether, mefloquine, quinine, haloperidol, etc.).
    • Monitor combination with omeprazole and antacids containing aluminium or magnesium hydroxide (effects of atazanavir decreased).
    • Atazanavir in combination with ritonavir reduces the efficacy of oral contraceptives: use a non-hormonal contraception or injectable medroxyprogesterone or an oral contraceptive containing at least 30 micrograms of ethinylestradiol per tablet.
    • Pregnancy: no contra-indication; monitor bilirubin levels and/or signs of jaundice in neonates.


    • Take with meals together with ritonavir.
    • Do not open the capsules.
    • Also comes in 300 mg capsules, not in combination with ritonavir.


    - Below 25 °C