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- Bronchodilator, anticholinergic drug
- Severe asthma attack, in combination with salbutamol
Forms and strengths
- Solution for inhalation, in unit dose vial of 0.25 mg in 1 ml (0.25 mg/ml) and 0.5 mg in 2 ml (0.25 mg/ml), to be administered via a nebuliser
Dosage and duration
- Child under 5 years: 0.25 mg (1 ml) per nebulisation every 20 minutes for the first hour
- Child 5 years and over and adult: 0.5 mg (2 ml) per nebulisation every 20 minutes for the first hour
Contra-indications, adverse effects, precautions
- May cause:
- throat irritation, headache, cough, vomiting;
- anticholinergic effects: dryness of the mouth, constipation, dilation of the pupils, blurred vision, urinary retention, tachycardia.
- Administer with caution to older patients and patients with closed-angle glaucoma, urethro-prostatic disorders, urinary retention.
- Avoid or monitor combination with drugs known to have anticholinergic effects: tricyclic antidepressants (e.g. amitriptyline), first generation H-1 antihistamines (e.g. hydroxyzine, promethazine),
- Pregnancy: no contra-indication
- Breast-feeding: no contra-indication
- Volumes of nebuliser solution to be administered are insufficient to obtain efficient nebulisation in most nebulisers: add ipratropium to salbutamol and then 0.9% sodium chloride to obtain a total volume of 5 ml in the reservoir of the nebuliser. Stop the nebulisation when the reservoir is empty (after around 10 to 15 minutes).
– Below 25 °C