CEFIXIME oral

Therapeutic action

• Third-generation cephalosporin antibacterial

Indications

• Typhoid fever
• Acute cystitis in girls over 2 years, pregnant women and lactating women
• Acute pyelonephritis in adults
• Cervicitis and urethritis due to Neisseria gonorrhoeae (in combination with a treatment for chlamydia)
• Second-line treatment of shigellosis

Forms and strengths

• 200 mg tablet
• 100 mg/5 ml powder for oral suspension, to be reconstituted with filtered water

Dosage

Typhoid fever

• Child: 10 mg/kg (max. 200 mg) 2 times daily
• Adult: 200 mg 2 times daily

Acute cystitis in girls over 2 years and shigellosis

• Child: 8 mg/kg (max. 400 mg) once daily
• Adult: 400 mg once daily

Acute cystitis in pregnant and lactating women, acute pyelonephritis in adult

• 200 mg 2 times daily

Cervicitis and urethritis due to Neisseria gonorrhoeae

• Child: 8 mg/kg (max. 400 mg) single dose
• Adult: 400 mg single dose

Duration

• Typhoid fever and acute pyelonephritis: 10 to 14 days
• Acute cystitis: 3 days for girls and 5 days for adults
• Shigellosis: 5 days

Contra-indications, adverse effects, precautions

• Do not administer to patients with allergy to cephalosporins.
• Administer with caution to penicillin-allergic patients (cross-sensitivity may occur) and in patients with severe renal impairment (reduce dosage).
• May cause: gastrointestinal disturbances (especially diarrhoea), headache, dizziness, allergic reactions (rash, pruritus, fever). In the event of allergic reaction, stop treatment immediately.
• Pregnancy: no contra-indication
• Breast-feeding: no contra-indication

Storage