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    Prescription under medical supervision


    Therapeutic action

    • Thiazide diuretic


    • Hypertension
    • Oedema associated with renal, hepatic or congestive heart failure

    Forms and strengths

    • 12.5 mg and 25 mg tablets



    • Adult: 12.5 to 25 mg once daily in the morning (max. 25 mg daily)


    Oedema associated with renal, hepatic or congestive heart failure

    • Adult: 25 mg once daily in the morning or 25 mg 2 times daily (max. 100 mg daily)


    • According to clinical response

    Contra-indications, adverse effects, precautions

    • Do not administer to patients with severe renal failure.
    • Administer with caution in patients with hypokalaemia, hyponatraemia and in elderly patients.
    • May cause:
      • dehydration, hypotension, hypokalaemia, hyponatraemia;
      • gastrointestinal disturbances, headache, dizziness, skin rash, impotence, photosensitivity.
    • Avoid or monitor combination with NSAIDs (risk of renal impairment); lithium (increased plasma concentrations of lithium). 
    • Monitor combination with:
      • drugs that provoke hypotension (e.g. haloperidol, amitriptyline) and antihypertensive drugs (risk of hypotension);
      • potassium-depleting drugs (e.g. corticosteriods, laxatives, amphotericin B), sodium-depleting drugs (e.g. SSRI, carbamazepine), drugs enhancing hypercalcemic effect (e.g. calcium, ergocalciferol);
      • oral antidiabetics and insulin (risk of hyperglycaemia).
    • Pregnancy: CONTRA-INDICATED
    • Breast-feeding: CONTRA-INDICATED


    • A potassium-rich diet (dates, bananas, mangos, oranges, tomatoes, etc.) is recommended during treatment. If potassium level is < 3.5 mmol/litre, administer a sustained-released potassium supplement. 
    • Diuretics are not indicated in the treatment of nutritional oedema.


    - Below 25 °C