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- Thiazide diuretic
- Oedema associated with renal, hepatic or congestive heart failure
Forms and strengths
- 12.5 mg and 25 mg tablets
- Adult: 12.5 to 25 mg once daily in the morning (max. 25 mg daily)
Oedema associated with renal, hepatic or congestive heart failure
- Adult: 25 mg once daily in the morning or 25 mg 2 times daily (max. 100 mg daily)
- According to clinical response
Contra-indications, adverse effects, precautions
- Do not administer to patients with severe renal failure.
- Administer with caution in patients with hypokalaemia, hyponatraemia and in elderly patients.
- May cause:
- dehydration, hypotension, hypokalaemia, hyponatraemia;
- gastrointestinal disturbances, headache, dizziness, skin rash, impotence, photosensitivity.
- Avoid or monitor combination with NSAIDs (risk of renal impairment); lithium (increased plasma concentrations of lithium).
- Monitor combination with:
- drugs that provoke hypotension (e.g. haloperidol, amitriptyline) and antihypertensive drugs (risk of hypotension);
- potassium-depleting drugs (e.g. corticosteriods, laxatives, amphotericin B), sodium-depleting drugs (e.g. SSRI, carbamazepine), drugs enhancing hypercalcemic effect (e.g. calcium, ergocalciferol);
- oral antidiabetics and insulin (risk of hyperglycaemia).
- Pregnancy: CONTRA-INDICATED
- Breast-feeding: CONTRA-INDICATED
- A potassium-rich diet (dates, bananas, mangos, oranges, tomatoes, etc.) is recommended during treatment. If potassium level is < 3.5 mmol/litre, administer a sustained-released potassium supplement.
- Diuretics are not indicated in the treatment of nutritional oedema.
- Below 25 °C