MEDROXYPROGESTERONE acetate oral

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    Last updated: October 2021

     

    Prescription under medical supervision

    Therapeutic action

    • Progestogen

    Indications

    • Abnormal uterine bleeding (especially functional uterine bleeding unrelated to pregnancy)

    Forms and strengths

    • 10 mg tablet

    Dosage and duration

    Persistent abnormal uterine bleeding despite tranexamic acid therapy or heavy bleeding when tranexamic acid is contra-indicated

    • Adolescent and adult: 20 mg 3 times daily for 7 days
       

    Long-term treatment of functional uterine bleeding 

    • Adult: 10 mg once daily (up to 30 mg once daily if necessary). Continue treatment according to clinical response.

    Contra-indications, adverse effects, precautions

    • Do not administer to patients with breast cancer, severe hypertension (≥ 160/100), active thromboembolic disorders, uncontrolled or complicated diabetes, severe or recent hepatic disease.
    • May cause: menstrual irregularities, amenorrhoea, menometrorrhagia, breast tenderness, headache, weight gain, acne, mood change, abdominal pain, gastrointestinal disturbances.
    • Pregnancy: CONTRA-INDICATED
    • Breast-feeding: no contra-indication

    Remarks

    • Unlike injectable medroxyprogesterone, the oral form has no contraceptive effect.

    Storage 

     
    – Below 25 °C 
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