ABACAVIR = ABC oral

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    Last updated: September 2021

     

    Prescription under medical supervision

     

     

    Therapeutic action

    • Antiretroviral, HIV nucleoside reverse transcriptase inhibitor

    Indications

    • HIV infection, in combination with other antiretroviral drugs

    Forms and strengths

    • 300 mg tablet

    Dosage

    • Adult: 300 mg 2 times daily or 600 mg once daily

    Duration

    • Depending on the efficacy and tolerance of abacavir.

    Contra-indications, adverse effects, precautions

    • Do not administer to patients with severe hepatic impairment or history of hypersensibility reaction to abacavir that led to discontinuation of treatment.
    • Administer with caution to patients with hypertension, diabetes, hyperlipidemia (might increase the risk of coronary disease).
    • May cause:
      • hypersensitivity reactions: fever, rash, gastrointestinal disturbances (nausea, vomiting, diarrhoea, abdominal pain), pharyngitis, cough, dyspnoea, malaise, headache, lethargy, myalgia, arthralgia;
      • lactic acidosis, pancreatitis and hepatic disorders.

    In all these cases, stop taking abacavir immediately and permanently.

    • Pregnancy: no contra-indication

    Remarks

    • Also comes in fixed-dose combinations (abacavir 120 mg/lamivudine 60 mg dispersible, breakable, paediatric tablet and abacavir 600 mg/lamivudine 300 mg tablet). Preferably use these formulations when available.

    Storage

     
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    - Below 25 °C 

     

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