- Analgesic, antipyretic, non steroidal anti-inflammatory (NSAID)
- Platelet antiaggregant (at low dose)
- Mild pain, fever
- Secondary prevention of severe pre-eclampsia
Forms and strengths
- 300 mg and 500 mg tablets
- 75 mg enteric coated tablet
Dosage and duration
Pain and fever:
Adolescent over 16 years and adult: 300 mg to 1 g every 4 to 6 hours (max. 4 g daily), for 1 to 3 days
Prevention of pre-eclampsia:
75 to 150 mg once daily from the 12th to the 36th week of gestation. Stop treatment 5 to 10 days before the expected date of delivery.
Contra-indications, adverse effects, precautions
- Do not administer to patients with allergy to aspirin and NSAID, peptic ulcer, coagulation disorders, haemorrhage, severe renal, hepatic or cardiac impairment.
- Do not administer to children for pain or fever (use paracetamol).
- Administer with caution to elderly patients or patients with asthma.
- Do not exceed indicated doses, particularly in elderly patients. Intoxications are severe, possibly fatal.
- May cause:
- allergic reactions, epigastric pain, peptic ulcer, haemorrhage;
- dizziness, tinnitus (early signs of overdose);
- Reye’s syndrome in children (encephalopathy and severe hepatic disorders).
For all cases above, stop aspirin.
- Do not combine with methotrexate, anticoagulants and NSAID.
- Monitor combination with insulin (increased hypoglycaemia) and corticosteroids.
- pain and fever: avoid. CONTRA-INDICATED from the beginning of the 6th month. Use paracetamol.
- prevention of pre-eclampsia: do not exceed 150 mg daily.
- Breast-feeding: avoid. Use paracetamol.
- Take during meals, preferably with a lot of water.
- Do not crush enteric coated tablets.
- Aspirin may be administered in secondary prevention of atherothrombosis, at a dose of 75 to 300 mg daily.
Do not use if tablets have a strong smell of vinegar. A slight vinegar smell is always present.