CLARITHROMYCIN oral

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    Prescription under medical supervision

     

    Therapeutic action

    • Macrolide antibacterial

    Indications

    • Eradication of Helicobacter pylori, in combination with omeprazole and amoxicillin

    Forms and strengths

    • 500 mg tablet

    Dosage and duration

    • Adult: 500 mg 2 times daily for 7 days

    Contra-indications, adverse effects, precautions

    • Do not administer to patients with allergy to clarithromycin or another macrolide.
    • May cause:
      • headache, taste disturbances, insomnia, gastrointestinal disturbances, reversible hearing disorders;
      • heart rhythm disorders (QT prolongation); 
      • hypersensitivity reactions sometimes severe (in this event, stop treatment immediately).
    • Administer with caution and reduce dosage by half in patients with severe renal impairment.
    • Avoid combination with drugs that prolong the QT interval: amiodarone, antimalarials, antipsychotics, efavirenz, fluconazole, fluoroquinolones, hydroxyzine, ondansetron, etc.
    • Administer with caution and monitor combination with: oral antidiabetics, atorvastatin, carbamazepine, daclatasvir, digoxin, phenytoin, rifabutin (increased plasma concentrations of these drugs).
    • Pregnancy: avoid (safety not established)
    • Breast-feeding: no contra-indication

    Remarks

    • Clarithromycin is also used for the treatment of non-tuberculous mycobacterial infections.

    Storage

    Below 25 °C