CLINDAMYCIN oral

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    Prescription under medical supervision

     

     

    Therapeutic action

    • Lincosamide antibacterial

    Indications

    • Severe staphylococcal and/or streptococcal infections (e.g. erysipelas, cellulitis, cutaneous anthrax, pneumonia):
      • in betalactam-allergic patients
      • in infections due to methicillin-resistant Staphylococcus aureus
    • Completion treatment following parental therapy with clindamycin

    Forms and strengths

    • 150 mg and 300 mg capsules

    Dosage

    • Child: 10 to 13 mg/kg 3 times daily 
    • Adult: 600 mg 3 times daily

     

    Age

    Weight

    150 mg capsule

    300 mg capsule

    1 to < 6 years

    10 to < 20 kg

    1 cap x 3

    6 to < 9 years

    20 to < 30 kg

    1 cap x 3

    9 to < 13 years

    30 to < 45 kg

    3 cap x 3

    ≥ 13 years and adult

    ≥ 45 kg

    2 cap x 3

     

    Duration

    • Erysipelas, cellulitis: 7 to 10 days
    • Cutaneous anthrax: 7 to 14 days depending on severity
    • Pneumonia: 10 to 14 days

    Contra-indications, adverse effects, precautions

    • Do not administer to patients with allergy to lincosamides or history of pseudomembranous colitis.
    • Reduce dosage in patients with hepatic impairment.
    • May cause: pseudomembranous colitis, rash, jaundice, severe allergic reactions. In these cases, stop treatment.
    • In the event of pseudomembranous colitis, treat for Clostridium difficile infection (oral metronidazole).
    • Do not administer simultaneously with antacids (aluminium or magnesium hydroxide, etc.). Administer 2 hours apart.
    • Pregnancy: no contra-indication
    • Breast-feeding: use only when there is no therapeutic alternative. Check infant’s stools (risk of pseudomembranous colitis).

    Remarks

    • Capsules are not suitable for children under 6 years (risk of aspiration). Open the capsule and mix the content into a spoon with food or fruit juice to mask the unpleasant taste.
    • Clindamycin is use in combination with quinine for the treatment of malaria in pregnant women (10 mg/kg 2 times daily for 7 days).
    • Also comes in 75 mg/5 ml oral suspension.

    Storage

     
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    - Below 25 °C