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- Sulfone antibacterial, antileprotic
Indications
- Prophylaxis of toxoplasmosis and pneumocystosis, in combination with pyrimethamine and folinic acid
- Treatment of pneumocystosis, in combination with trimethoprim
- Paucibacillary and multibacillary leprosy, in combination with rifampicin and clofazimine
Forms and strengths
- 50 mg and 100 mg tablets
Dosage
Prophylaxis of pneumocystosis only
- Child: 2 mg/kg once daily (max. 100 mg daily)
- Adult: 100 mg once daily
Prophylaxis of toxoplasmosis and pneumocystosis
- Child: 2 mg/kg once daily (max. 25 mg daily)
- Adult: 200 mg once weekly or 50 mg once daily
Treatment of pneumocystosis
- Child: 2 mg/kg once daily (max. 100 mg daily)
- Adult: 100 mg once daily
Paucibacillary and multibacillary leprosy
- Child under 10 years: 2 mg/kg once daily
- Child from 10 to 14 years: 50 mg once daily
- Child 15 years and over and adult: 100 mg once daily
Duration
- Prophylaxis of toxoplasmosis and pneumocystosis: as long as necessary
- Treatment of pneumocystosis: 21 days
- Paucibacillary leprosy: 6 months
- Multibacillary leprosy: 12 months
Contra-indications, adverse effects, precautions
- Do not administer to patients with allergy to sulfones or severe anaemia (first treat anaemia).
- Administer with caution to patients with renal or hepatic impairment.
- May cause: haemolytic anaemia in patients with G6PD deficiency, dose-related haemolytic anaemia, neutropenia, methaemoglobinaemia, pruritus, rash, gastrointestinal disturbances, peripheral neuropathies, agranulocytosis; hypersensitivity reactions during the first month of treatment (fever, jaundice, hepatitis, adenopathy, exfoliative dermatitis, etc.) requiring permanent discontinuation of treatment.
- Monitor blood count and transaminases if possible.
- Monitor combination with zidovudine (increased haematological toxicity).
- Pregnancy: no contra-indication
- Breast-feeding: no contra-indication
Storage
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– Below 25 °C