On this page
Therapeutic action
- Antiemetic (dopamine antagonist)
Indications
- Symptomatic treatment of nausea and vomiting in adults
Forms and strengths
- 10 mg tablet
Dosage
- Adult under 60 kg: 5 mg 3 times daily
- Adult over 60 kg: 10 mg 3 times daily
The interval between each dose should be at least 6 hours (even in the event of vomiting).
Duration
- Max. 5 days
Contra-indications, adverse effects, precautions
- Do not administer to children < 18 years and to patients with gastrointestinal haemorrhage, obstruction or perforation.
- Reduce the dose by half in patients with severe renal impairment.
- Administer with caution and monitor use in patients > 60 years and patients with epilepsy or Parkinson's disease.
- May cause: drowsiness (caution when driving/operating machinery), dizziness, confusion, extrapyramidal symptoms, seizures (especially in patients with epilepsy), allergic reactions; neuroleptic malignant syndrome (unexplained hyperthermia with neuromuscular disorders), exceptional but requiring immediate treatment discontinuation.
- Do not combine with levodopa (antagonism).
- Avoid combination with CNS depressants (opioid analgesics, antipsychotics, sedatives, antidepressants, antihistamines, etc.).
- Avoid alcohol during treatment (increased risk of adverse effects).
- Pregnancy: no contra-indication
- Breast-feeding: no contra-indication