PHENOXYMETHYLPENICILLIN = PENICILLIN V oral

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    Last updated: January 2024

     

    Prescription under medical supervision

     

    Therapeutic action

    • Penicillin antibacterial

    Indications

    • Streptococcal pharyngitis, scarlet fever
    • Alternative to first-line antibiotic treatment of diphtheria
    • Completion treatment following parenteral therapy with penicillin

    Forms and strengths

    • 250 mg tablet (400 000 IU)
    • Powder for oral suspension, 125 mg/5 ml (200 000 IU/5 ml): ,
      • to be reconstituted with filtered water
      • to be administered using a measuring device (oral syringe, measuring spoon, or cup with graduations)

    Dosage

    Streptococcal pharyngitis, scarlet fever

     

    Age

    Weight

    Daily dose

    125 mg/5 ml

    oral susp.

    250 mg tablet

    < 1 year

    < 10 kg

    125 mg x 2

    5 ml x 2

    1 to < 6 years

    10 to < 21 kg

    250 mg x 2

    10 ml x 2

    6 to < 12 years

    21 to < 39 kg

    500 mg x 2

    20 ml x 2

    2 tab x 2

    ≥ 12 years and adult

    ≥ 39 kg

    1 g x 2

    4 tab x 2


    Diphtheria

    • Child under 40 kg: 10 to 15 mg/kg (max. 500 mg) 4 times daily
    • Child 40 kg and over and adult: 500 mg 4 times daily

    Duration

    • Streptococcal pharyngitis, scarlet fever: 10 days
    • Diphtheria: 14 days

    Contra-indications, adverse effects, precautions

    • Do not administer to patients with allergy to penicillin.
    • Administer with caution to patients with allergy to cephalosporin (cross-sensitivity may occur) or severe renal impairment (reduce dose).
    • May cause: diarrhea, nausea; allergic reactions sometimes severe.
    • Do not combine with methotrexate.
    • Pregnancy: no contra-indication
    • Breast-feeding: no contra-indication

    Remarks

    • Take between meals.
    • Phenoxymethylpenicillin is also used in children for the prevention of pneumococcal infections in sickle cell disease and recurrence of acute rheumatic fever.

    Storage

     
    –  
     
    –  Below 25 °C

    For the oral suspension (powder or reconstituted suspension): follow manufacturer’s instructions.