PRAZIQUANTEL oral

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    Prescription under medical supervision

     

    Therapeutic action

    • Anthelminthic

    Indications

    • Urinary (S. haematobium) and intestinal (S. mansoni, S. japonicum, S. mekongi, S. intercalatum) schistosomiasis
    • Taeniasis (T. saginata, T. solium, D. latum, H. nana)
    • Pulmonary (P. westermani), hepatobiliary (O. felineus, O. viverrini, C. sinensis) and intestinal (F. buski, H. heterophyes, M. yokogawai) flukes

    Forms and strengths

    • 600 mg breakable tablet

    Dosage and duration

    Child 4 years and over and adult:

     

    Schistosomiasis

    • S. haematobium, S. mansoni, S. intercalatum: 40 mg/kg single dose or 2 doses of 20 mg/kg administered 4 hours apart
    • S. japonicum, S. mekongi: 2 doses of 30 mg/kg or 3 doses of 20 mg/kg administered 4 hours apart
       

    Taeniase

    • T. saginata, T. solium, D. latum: 5 to 10 mg/kg single dose
    • H. nana: 15 to 25 mg/kg single dose
       

    Fluke infections

    • lung and hepatobiliary: 25 mg/kg 3 times daily for 2 days
    • intestinal: 25 mg/kg 3 times daily, 1 day

    Contra-indications, adverse effects, precautions

    • Do not administer to patients with ocular cysticercosis.
    • May cause:
      • drowsiness, headache, gastrointestinal disturbances, dizziness; rarely: allergic reactions;
      • neurological disorders (headache, seizures) in patients with undiagnosed neuro cysticercosis.
    • Pregnancy: no contra-indication for the treatment of schistosomiasis and taeniasis. If immediate treatment not considered essential for fluke infections, it should be delayed until after delivery.
    • Breast-feeding: no contra-indication

    Remarks

    • Do not chew the tablets due to their bitter taste. Take during meals.
    • Praziquantel is not active against certain liver flukes (Fasciola hepatica and gigantica). For this indication, use triclabendazole.

    Storage

     
    –  Below 30 °C