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- Sulfonamide antibacterial
- Treatment and secondary prophylaxis of toxoplasmosis in immunodeficient patients, in combination with pyrimethamine
Forms and strengths
- 500 mg tablet
Dosage and duration
Treatment of toxoplasmosis
- Adult: 2 g 2 to 3 times daily for 6 weeks minimum
Secondary prophylaxis of toxoplasmosis
- Adult: 1 to 1.5 g 2 times daily, as long as necessary
Contra-indications, adverse effects, precautions
- Do not administer to sulfonamide-allergic patients; patients with severe renal or hepatic impairment.
- May cause:
- gastrointestinal disturbances, renal disorders (crystalluria, etc.), photosensitivity, megaloblastic anaemia due to folic acid deficiency; haemolytic anaemia in patients with G6PD deficiency;
- allergic reactions (fever, rash, etc.) sometimes severe (Lyell's and Stevens-Johnson syndromes, haematological disorders, etc.). In these cases, stop treatment immediately.
- Adverse effects occur more frequently in patients with HIV infection.
- Monitor blood count if possible.
- Reduce the dose by half in patients with renal impairment.
- Do not combine with methotrexate and phenytoin.
- Administer calcium folinate systematically to prevent folic acid deficiency.
- Drink a lot of liquid during treatment.
- Pregnancy: no contra-indication. However, avoid using during the last month of pregnancy (risk of jaundice and haemolytic anaemia in the newborn infant).
- Breast-feeding: avoid if preterm infant, jaundice, low-birth weight, infant under one month of age. If sulfadiazine is used, observe the infant for signs of jaundice.
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