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- Antiretroviral, HIV nucleotide reverse transcriptase inhibitor
- HIV infection, in combination with other antiretrovirals
- Post-exposure prophylaxis (PEP) and pre-exposure prophylaxis (PrEP), in combination with lamivudine (3TC) or emtricitabine (FTC)
Forms and strengths
- 300 mg tablet, equivalent to 245 mg of tenofovir disoproxil
Also comes in fixed-dosed combinations containing tenofovir for HIV treatment.
- Child 35 kg and over and adult: 300 mg once daily
- The duration of treatment depends on the efficacy and tolerance of tenofovir.
Contra-indications, adverse effects, precautions
- Administer with caution in patients with renal impairment.
- Monitor renal function. In the event of deterioration of renal function, switch to another antiretroviral.
- Avoid combination (or monitor renal function in the event of combination) with nephrotoxic drugs: aminoglycosides (e.g. gentamicin, streptomycin), amphotericin B, pentamidine, etc.
- May cause:
- gastrointestinal disturbances (nausea, vomiting, diarrhoea, etc.), dizziness, fatigue, skin rash;
- renal impairment, bone loss (osteoporosis, fractures), pancreatitis.
- Administer with caution and monitor use with NSAID (addition of nephrotoxic activity).
- Pregnancy: no contra-indication
- Tenofovir disoproxil is used alone for the treatment of chronic hepatitis B.
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