TINIDAZOLE oral

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    Prescription under medical supervision

     

    Therapeutic action

    • Antiprotozoal, antibacterial (group of nitroimidazoles)

    Indications

    • Amoebiasis, giardiasis, trichomoniasis
    • Bacterial vaginitis, infections due to anaerobic bacteria (e.g. Clostridium sp, Bacteroides sp)

    Forms and strengths

    • 500 mg tablet

    Dosage and duration

    Amoebiasis

    • Child: 50 mg/kg once daily (max. 2 g daily)
    • Adult: 2 g once daily

     

    The treatment lasts 3 days in intestinal amoebiasis; 5 days in hepatic amoebiasis.

     

    Giardiasis, trichomoniasis and bacterial vaginitis

    • Child: 50 mg/kg single dose (max. 2 g)
    • Adult: 2 g single dose

     

    In the event of trichomoniasis, also treat sexual partner.

     

    Infections due to anaerobic bacteria

    • Child over 12 years and adult: 2 g on D1 then 1 g once daily or 500 mg 2 times daily

     

    According to indication, tinidazole may be used in combination with other antibacterials; treatment duration depends on indication.

    Contra-indications, adverse effects, precautions

    • Do not administer to patients with allergy to tinidazole or another nitroimidazole (metronidazole, secnidazole, etc.).
    • May cause: gastrointestinal disturbances; rarely: allergic reactions, brownish urine, headache, dizziness. Risk of antabuse reaction when combined with alcohol.
    • Administer with caution in patients taking oral anticoagulants (risk of haemorrhage), lithium, phenytoin (increased plasma concentrations of these drugs).
    • Pregnancy: no contra-indication; divide into smaller doses, avoid prolonged use.
    • Breast-feeding: significantly excreted in milk (risk of gastrointestinal disturbances in breastfed infants); divide into smaller doses, avoid prolonged use.

    Storage

     
    –  Below 25 °C