ACETYLSALICYLIC acid = ASPIRIN = ASA oral

Prescription under medical supervision


Therapeutic action

– Analgesic, antipyretic, non steroidal anti-inflammatory (NSAID)
– Platelet antiaggregant (at low dose)

Indications

– Mild pain, fever
– Secondary prevention of severe pre-eclampsia

Forms and strengths

– 300 mg and 500 mg tablets
– 75 mg enteric coated tablet

Dosage and duration

– Pain and fever
Adolescent over 16 years and adult: 300 mg to 1 g every 4 to 6 hours (max. 4 g daily), for 1 to 3 days

– Prevention of pre-eclampsia
75 to 150 mg once daily from the 12th to the 36th week of gestation. Stop treatment 5 to 10 days before the expected date of delivery. 

Contra-indications, adverse effects, precautions

– Do not administer to patients with allergy to aspirin and NSAID, peptic ulcer, coagulation disorders, haemorrhage, severe renal, hepatic or cardiac impairment.
– Do not administer to children for pain or fever (use paracetamol).
– Administer with caution to elderly patients or patients with asthma.
– Do not exceed indicated doses, particularly in elderly patients. Intoxications are severe, possibly fatal.
– May cause:
• allergic reactions, epigastric pain, peptic ulcer, haemorrhage;
• dizziness, tinnitus (early signs of overdose);
• Reye’s syndrome in children (encephalopathy and severe hepatic disorders).
For all cases above, stop aspirin.
– Do not combine with methotrexate, anticoagulants and NSAID.
– Monitor combination with insulin (increased hypoglycaemia) and corticosteroids.
– Pregnancy:
• pain and fever: avoid. CONTRA-INDICATED from the beginning of the 6th month. Use paracetamol.
• prevention of pre-eclampsia: do not exceed 150 mg daily.
– Breast-feeding: avoid. Use paracetamol.

Remarks

– Take during meals, preferably with a lot of water.
– Do not crush enteric coated tablets.
– Aspirin may be administered in secondary prevention of atherothrombosis, at a dose of 75 to 300 mg daily.
  Storage: below 25 °C - 
Do not use if tablets have a strong smell of vinegar. A slight vinegar smell is always present.