ARTEMETHER/LUMEFANTRINE = AL oral

Prescription under medical supervision


Therapeutic action

– Antimalarial

Indications

– Treatment of uncomplicated falciparum malaria
– Treatment of uncomplicated malaria due to other Plasmodium species, when chloroquine cannot be used
– Completion treatment following parenteral therapy for severe malaria

Forms and strengths

– Co-formulated tablets of artemether/lumefantrine, in blister packs, for a complete treatment for one individual

– There are 5 different blister packs corresponding to 4 different categories of weight:
• 20 mg artemether/120 mg lumefantrine dispersible tablet, blister pack of 6 tablets
• 20 mg artemether/120 mg lumefantrine dispersible tablet, blister pack of 12 tablets
• 20 mg artemether/120 mg lumefantrine tablet, blister pack of 18 tablets
• 20 mg artemether/120 mg lumefantrine tablet, blister pack of 24 tablets
• 80 mg artemether/480 mg lumefantrine tablet, blister pack of 6 tablets

Dosage and duration

– The treatment is administered 2 times daily for 3 days. On D1, the first dose is given at 0 hour and the second dose at 8-12 hours. Subsequent doses on D2 and D3 are given 2 times daily (morning and evening).


Weight
20/120 mg tablet80/480 mg tablet

D1

D2

D3

D1

D2

D3

5 to < 15 kg

1 disp tab x 2

1 disp tab x 2

1 disp tab x 2

15 to < 25 kg

2 disp tab x 2

2 disp tab x 2

2 disp tab x 2

25 to < 35 kg

3 tab x 2

3 tab x 2

3 tab x 2

≥ 35 kg

4 tab x 2

4 tab x 2

4 tab x 2

1 tab x 2

1 tab x 2

1 tab x 2

Contra-indications, adverse effects, precautions

May cause: headache, dizziness and gastrointestinal disturbances.
– Administer with caution to patients taking drugs that prolong the QT interval: amiodarone, other antimalarials, antipsychotics, fluconazole, fluoroquinolones, hydroxyzine, macrolides, ondansetron, etc.
– If the patient vomits within 30 minutes after administration:
re-administer the full dose. If the patient vomits between 30 minutes and 1 hour after administration, re-administer half of the dose.
Pregnancy: no contra-indication
Breast-feeding: no contra-indication

Remarks

– Take with meals or a fat containing drink (e.g. milk).
– Lumefantrine is also called co-artemether.
  Storage: below 30 °C -  - 
Leave tablets in blisters until use. Once a tablet is removed from its blister, it must be administered immediately.