– Anticholinergic antiparkinson drug
– First-line treatment of extrapyramidal reactions induced by antipsychotics
Forms and strengths
– 2 mg tablet
– Adult: 2 mg once daily, then increase if necessary up to 2 mg 2 to 3 times daily (max. 12 mg daily)
– Administer at the lowest effective dose in elderly patients and do not exceed 10 mg daily.
– As long as the antipsychotic treatment lasts.
Contra-indications, adverse effects, precautions
– Do not administer to patients with closed-angle glaucoma, prostate disorders, gastrointestinal obstruction or atony.
– Administer with caution and carefully monitor use in elderly patients (risk of confusion, hallucinations).
– May cause: anticholinergic effects (dry mouth, constipation, blurred vision, tachycardia, disorders of micturition), confusion, hallucinations, memory impairment.
– Avoid or monitor combination with other drugs known to have anticholinergic effects (atropine, amitriptyline, chlorpromazine, promethazine, etc.).
– Pregnancy: re-evaluate whether the antipsychotic treatment is still necessary; if treatment is continued, administer biperiden at the lowest effective dose and observe the child if the mother was under treatment in the 3rd trimester (risk of anticholinergic effect, e.g. tremors, abdominal distension).
– Breast-feeding: if treatment is necessary, administer at the lowest effective dose and observe the child (risk of anticholinergic effects, e.g. tachycardia, constipation, thickening of bronchial secretions).
– Also comes in 4 mg extended-release tablet, administered once daily.
– Biperiden is also used in the treatment of Parkinson’s disease.
– Storage: below 25 °C - -