CALCIUM FOLINATE = FOLINIC acid oral

Prescription under medical supervision


Therapeutic action

– Antidote to folate antagonists

Indications

– Prevention of haemotological toxicity of pyrimethamine when pyrimethamine is used as prophylaxis for, or in the treatment of toxoplasmosis or isosporiasis in immunodeficient patients

Forms and strengths

– 15 mg tablet
Also comes in 5 mg and 25 mg capsules.

Dosage

– When pyrimethamine is used as primary or secondary prophylaxis for toxoplasmosis
Adult: 25 to 30 mg once weekly

– During treatment of toxoplasmosis
Adult: 10 to 25 mg once daily

– During treatment of isosporiasis
Adult: 5 to 15 mg once daily

Duration

– For the duration of the pyrimethamine treatment

Contra-indications, adverse effects, precautions

– Pregnancy: no contra-indication
– Breast-feeding: no contra-indication

Remarks

– Folic acid cannot be used as an alternative to folinic acid for the treatment of toxoplasmosis: folic acid reduces the antiprotozoal activity of pyrimethamine.
– Calcium folinate is also called calcium leucovorin.
  Storage: below 25 °C -