Prescription under medical supervision

Therapeutic action

– Macrolide antibacterial


– Eradication of Helicobacter pylori, in combination with omeprazole and amoxicillin

Forms and strengths

– 500 mg tablet

Dosage and duration

– Adult: 500 mg 2 times daily for 7 days

Contra-indications, adverse effects, precautions

– Do not administer to patients with allergy to clarithromycin or another macrolide.
– May cause:
headache, taste disturbances, insomnia, gastrointestinal disturbances, reversible hearing disorders;
heart rhythm disorders (QT prolongation);
hypersensitivity reactions sometimes severe (in this event, stop treatment immediately).
– Administer with caution and reduce dosage by half in patients with severe renal impairment.
– Avoid combination with drugs that prolong the QT interval: amiodarone, antimalarials, antipsychotics, efavirenz, fluconazole, fluoroquinolones, hydroxyzine, ondansetron, etc.
– Administer with caution and monitor combination with: oral antidiabetics, atorvastatin, carbamazepine, daclatasvir, digoxin, phenytoin, rifabutin (increased plasma concentrations of these drugs).
– Pregnancy: avoid (safety not established)
– Breast-feeding: no contra-indication


– Clarithromycin is also used for the treatment of non-tuberculous mycobacterial infections.
– Storage: below 25 °C