– Anxiolytic, sedative, anticonvulsant, muscle relaxant
– Severe anxiety, insomnia and agitation
Forms and strengths
– 2 mg and 5 mg tablets
Dosage and duration
Adult: 2.5 to 5 mg 2 times daily for 1 to 2 weeks max. reducing the dose by half the last days before stopping treatment
Adult: 2 to 5 mg once daily at bedtime for 7 days max.
Adult: 10 mg single dose
Contra-indications, adverse effects, precautions
– Do not administer to patients with severe respiratory insufficiency or severe hepatic impairment.
– Administer with caution and reduce the dose by half in elderly patients and in patients with renal or hepatic impairment.
– May cause:
• drowsiness, impaired concentration, memory loss, confusion, muscle weakness;
• dependence and tolerance when used for more than 2 weeks;
• withdrawal syndrome or rebound effect if prolonged treatment is discontinued abruptly;
• ataxia, hypotonia, hypotension, confusion, lethargy, respiratory depression, coma in the event of overdose.
– Monitor combination with:
• drugs acting on the central nervous system: opioid analgesics, antipsychotics (chlorpromazine, haloperidol, etc.), antihistamines (chlorphenamine, promethazine), antidepressants (fluoxetine, etc.), phenobarbital, etc.;
• fluconazole, erythromycin, omeprazole, ritonavir, isoniazide (effect of diazepam increased);
• phenobarbital (effect of diazepam decreased).
– Avoid alcohol during treatment.
– Pregnancy and breast-feeding: avoid
– Diazepam is subject to international controls: follow national regulations.
– Diazepam is not a treatment for depression, chronic anxiety, post-traumatic stress disorder, psychosis.
– Storage: below 25 °C - -