– Supraventricular arrhythmias (fibrillation, flutter, paroxysmal tachycardia)
– Heart failure
Forms and strengths
– 250 micrograms (0.25 mg) tablet
– Adult: 125 to 250 micrograms (0.125 to 0.25 mg) once daily
– Reduce the dose by half in elderly patients and in patients with renal impairment.
– According to clinical response
Contra-indications, adverse effects, precautions
– Do not administer to patients with bradycardia, ill defined arrhythmia, coronary artery disease.
– It is essential to monitor pulse in the initial stage of treatment.
– Narrow margin between therapeutic and toxic dose.
– May cause in the event of overdose: gastrointestinal disturbances (nausea, vomiting, diarrhoea), blurred vision, headache, confusion, conduction and rhythm disorders. If so, reduce dose or stop treatment.
– Do not combine with calcium, particularly by IV route (serious arrhythmias).
– Monitor combination with:
• amiodarone, macrolides, itraconazole, quinine, chloroquine (increased digoxin concentration);
• potassium-depleting drugs: diuretics, corticoids, amphotericin B (increased risk of digoxin toxicity).
– Monitor if possible serum potassium level in patients taking potassium-depleting drugs and serum creatinine level in patients with renal impairment.
– Do not administer simultaneously with antacids such as aluminium hydroxide, etc., administer 2 hours apart.
– Pregnancy: no contra-indication
– Breast-feeding: no contra-indication
– Storage: below 25 °C -