Prescription under medical supervision

Therapeutic action

– Angiotensin converting enzyme inhibitor (ACE)


– Hypertension
– Chronic heart failure

Forms and strengths

– 5 mg and 20 mg tablets


– Hypertension
• Adult: start with 5 mg once daily, then increase the dose gradually every 1 to 2 weeks, according to blood pressure, up to 10 to 20 mg once daily (max. 40 mg daily)
• In elderly patients, patients taking a diuretic or patients with renal impairment: start with 2.5 mg once daily then adapt dose according to renal function.

– Chronic heart failure
Week 1: 2.5 mg once daily for 3 days then 5 mg once daily 
Week 2: 10 mg once daily for 3 days then 20 mg once daily
The usual dose is 10 to 20 mg once daily or 5 to 10 mg 2 times daily depending on tolerance (max. 40 mg daily). 
Reduce dosage in patients with renal impairment.


– According to clinical response

Contra-indications, adverse effects, precautions

– Do not administer to patients with history of enalapril-related angioedema.
– May cause:
• hypotension, dizziness, headache, gastrointestinal disturbances, dry cough, renal impairment, hyperkalaemia, hyponatraemia;
• allergic reactions, angioedema; hypoglycaemia, haematological disorders. 
– Avoid or monitor combination with: potassium-sparing diuretics and/or potassium chloride (risk of hyperkalaemia); non steroidal anti-inflammatory drugs and/or diuretics (risk of renal impairment).
– Monitor combination with: 
• other antihypertensive drugs (risk of hypotension);
• drugs that provoke hypotension (e.g. haloperidol, amitriptyline);
• oral antidiabetics and insulin (risk of hypoglycaemia).
– Breast-feeding: no contra-indication at recommended doses


  Storage: below 25 °C -