FERROUS salts


Therapeutic action

– Antianaemia drug

Indications

– Prevention of iron-deficiency
– Treatment of iron-deficiency anaemia

Forms and strengths

– 140 mg/5 ml syrup of ferrous fumarate containing approximately 45 mg/5 ml of elemental iron
– 200 mg ferrous fumarate or sulfate tablet containing approximately 65 mg of elemental iron

Dosage

(expressed as elemental iron)

– Prevention of iron-deficiency
Neonate: 4.5 mg once daily
Child 1 month to < 12 years: 1 to 2 mg/kg once daily (max. 65 mg daily)
Child ≥ 12 years and adult: 65 mg once daily

– Treatment of iron-deficiency anaemia
Neonate: 1 to 2 mg/kg 2 times daily
Child 1 month to < 6 years: 1.5 to 3 mg/kg 2 times daily
Child 6 to < 12 years: 65 mg 2 times daily
Child ≥ 12 years and adult: 65 mg 2 to 3 times daily


Age


Weight

PreventionTreatment
45 mg/5 ml syrup65 mg tablet45 mg/5 ml syrup65 mg tablet
< 1 month< 4 kg0.5 ml0.5 ml x 2
1 month to < 1 year4 to < 10 kg1 ml1.5 ml x 2
1 to < 6 years10 to < 20 kg2.5 ml2.5 ml x 2
6 to < 12 years20 to < 40 kg5 ml1 tab x 2
≥ 12 years and adult≥ 40 kg1 tab1 tab x 2 or 3

Duration

– Prevention: during risk period (pregnancy, malnutrition)
– Treatment: 3 months

Contra-indications, adverse effects, precautions

– Do not administer to patients with other forms of anaemia. 
– May cause: abdominal pain, nausea, vomiting, diarrhoea or constipation, black stools.
– Do not exceed recommended doses in children (risk of overdose). 20 mg/kg of elemental iron (60 mg/kg of ferrous fumarate or sulfate) is considered toxic.
– Do not give simultaneously with doxycycline, ciprofloxacin, dolutegravir, antacids (aluminium hydroxide or magnesium, etc.), levodopa or zinc sulfate (reduced absorption of both drugs). Administer each drug at least 2 hours apart.
– Adminstration in combination with ascorbic acid (vitamin C) increases iron absorption.
– Rince mouth or drink water after administration of syrup (risk of tooth staining).
 Pregnancy and breast-feeding: no contra-indication

Remarks

– To reduce gastrointestinal disturbances, take during meals and gradually increase dosage.
– For the prevention of iron-deficiency during pregnancy, preferably use tablets containing both ferrous salts and folic acid.
– Storage: below 25 °C -