GLYCERYL TRINITRATE = NITROGLYCERIN = TRINITRIN oral

Prescription under medical supervision


Therapeutic action

– Vasodilator, antianginal

Indications

– Short-term prophylaxis and treatment of angina

Forms and strengths

– 0.5 mg sublingual tablet

Dosage

– Short-term prophylaxis of acute angina
Adult: 0.5 to 1 mg taken 5 to 10 minutes before a precipitating event (physical exertion, stress, etc.)

– Treatment of acute angina
Adult: 0.5 to 1 mg, to be repeated 1 to 3 times at 3-4 minute intervals

Do not exceed 3 mg daily.

Duration

– According to clinical response

Contra-indications, adverse effects, precautions

– Do not administer to patients with obstructive cardiomyopathy, hypotension, shock.
– May cause: orthostatic hypotension (especially in elderly patients), headache, nausea, flushing of the face, haemolytic anaemia in patients with G6PD deficiency, severe hypotension with risk of circulatory collapse in the event of overdose.
– Use the lowest effective dose in patients taking another nitrate derivative, a vasodilator or an antihypertensive drug and in elderly patients.
– Combination with antihypertensive drugs, diuretics, vasodilators and alcohol enhances hypotensive effects.
– Do not combine with sildenafil (risk of acute coronary syndrome).
 Pregnancy: not recommended (safety is not established)
– Breast-feeding: not recommended (safety is not established)

Remarks

– Tablet must be crunched first, then slowly dissolved under the tongue.
– Antianginal effect appears within less than 5 minutes and persists for less than 1 hour.
– Sustained-release formulations are used for the long-term management of angina and the treatment of heart failure.
– Storage: below 25 °C, preferably in airtight glass container -  -