HYDROCHLOROTHIAZIDE oral

Prescription under medical supervision


Therapeutic action

– Thiazide diuretic

Indications

– Hypertension
– Oedema associated with renal, hepatic or congestive heart failure

Forms and strengths

– 12.5 mg and 25 mg tablets

Dosage

– Hypertension
Adult: 12.5 to 25 mg once daily in the morning (max. 25 mg daily)

– Oedema associated with renal, hepatic or congestive heart failure
Adult: 25 mg once daily in the morning or 25 mg 2 times daily (max. 100 mg daily)

Duration

– According to clinical response

Contra-indications, adverse effects, precautions

– Do not administer to patients with severe renal failure.
– Administer with caution in patients with hypokalaemia, hyponatraemia and in elderly patients.
– May cause:
• dehydration, hypotension, hypokalaemia, hyponatraemia;
• gastrointestinal disturbances, headache, dizziness, skin rash, impotence, photosensitivity.
– Avoid or monitor combination with NSAIDs (risk of renal impairment); lithium (increased plasma concentrations of lithium). 
– Monitor combination with:
• drugs that provoke hypotension (e.g. haloperidol, amitriptyline) and antihypertensive drugs (risk of hypotension);
• potassium-depleting drugs (e.g. corticosteriods, laxatives, amphotericin B), sodium-depleting drugs (e.g. SSRI, carbamazepine), drugs enhancing hypercalcemic effect (e.g. calcium, ergocalciferol);
• oral antidiabetics and insulin (risk of hyperglycaemia).
– Pregnancy: CONTRA-INDICATED
– Breast-feeding: CONTRA-INDICATED

Remarks

– A potassium-rich diet (dates, bananas, mangos, oranges, tomatoes, etc.) is recommended during treatment. If potassium level is < 3.5 mmol/litre, administer a sustained-released potassium supplement. 
– Diuretics are not indicated in the treatment of nutritional oedema.
– Storage: below 25 °C -