Prescription under medical supervision

Therapeutic action

– Sedating H-1 antihistamine


– Anxiety

Forms and strengths

– 25 mg tablet


– Adult: 25 to 50 mg 2 times daily (max. 100 mg daily)
– Reduce the dose by half in elderly patients.


– As short as possible; do not exceed 2 weeks.

Contra-indications, adverse effects, precautions

– Do not administer to patients with closed-angle glaucoma, prostate disorders, dementia, history of QT interval prolongation.
– Do not combine with drugs that prolong the QT interval (amiodarone, co-artemether, erythromycin, fluconazole, haloperidol, mefloquine, pentamidine, quinine, etc.). 
– Administer with caution (max. 50 mg daily) and monitor use in patients with hepatic impairment or severe renal impairment.
– May cause:
• drowsiness, headache, dizziness;
• anticholinergic effects (dry mouth, constipation, blurred vision, tachycardia, disorders of micturition);
• rarely: seizures, QT interval prolongation, allergic reactions.
– Administer with caution and monitor combination with:
• central nervous system depressants (opioid analgesics, sedatives, etc.);
• anticholinergic drugs (atropine, amitriptyline, chlorpromazine, promethazine, etc.). 
– Avoid alcohol during treatment.
– Pregnancy and breast-feeding: avoid


– Storage: below 25 °C -  -