LOPERAMIDE oral

Prescription under medical supervision


Therapeutic action

– Opioid antidiarrhoeal

Indications

– Symptomatic treatment of persistent diarrhoea in HIV patients, in combination with rehydration

Forms and strengths

– 2 mg capsule or tablet
Also comes in 1 mg/5 ml oral solution.

Dosage

– Child from 2 to 5 years: 1 mg 3 times daily
– Child from 6 to 8 years: 2 mg 2 times daily
– Child over 8 years: 2 mg 3 times daily

Age

Weight

0-2 years

< 13 kg

2-5 years

13 - 20 kg

6-8 years

20 - 30 kg

> 8 years

> 30 kg

Oral solution

Do not
administer

1 tsp x 3

2 tsp x 2

2 tsp x 3

Capsule

1 cap x 2

1 cap x 3

– Adult: 4 mg (2 capsules), then 2 mg (1 capsule) after each loose stool, without exceeding 16 mg daily (8 capsules daily)

Duration

– According to clinical response

Contra-indications, adverse effects, precautions

– Do not exceed indicated doses.
– Do not administer to children under 2 years.
– Do not administer to patients with bloody diarrhoea, acute inflammatory bowel disease, diarrhoea due to antibiotics.
– May cause: constipation, allergic skin reactions, drowsiness, dizziness.
– In the event of overdosage, treat with naloxone.
 Pregnancy: no contra-indication
– Breast-feeding: no contra-indication

Remarks

– Rehydration is essential and must be adapted to the severity of diarrhoea.
– Loperamide is not included in the WHO list of essential medicines.
– Storage: below 25 °C -