Prescription under medical supervision

Therapeutic action

– Antiprotozoal, antibacterial (group of nitroimidazoles)


– Amoebiasis, giardiasis, trichomoniasis
– Bacterial vaginitis, infections due to anaerobic bacteria (e.g. Clostridium sp, Bacteroides sp, etc.)

Forms and strengths

– 250 mg and 500 mg tablets
– 200 mg/5 ml oral suspension

Dosage and duration

Child: 15 mg/kg 3 times daily
Adult: 500 mg 3 times daily
The treatment lasts 5 days in intestinal amoebiasis and 5 to 10 days in hepatic amoebiasis.

– Giardiasis
Child: 30 mg/kg once daily for 3 days
Adult: 2 g once daily for 3 days

– Trichomoniasis and bacterial vaginitis
Adult: 2 g single dose
In the event of trichomoniasis, also treat sexual partner.

– Infections due to anaerobic bacteria
Child: 10 mg/kg 3 times daily
Adult: 500 mg 3 times daily
According to indication, metronidazole may be used in combination with other anti bacterials; treatment duration depends on indication.

Contra-indications, adverse effects, precautions

– Do not administer to patients with hypersensitivity to metronidazole or another nitroimidazole (tinidazole, secnidazole, etc.).
– May cause: gastrointestinal disturbances; rarely: allergic reactions, brownish urine, headache, dizziness. Risk of antabuse reaction when combined with alcohol.
– Administer with caution in patients taking oral anticoagulants (risk of haemorrhage), lithium, phenytoin, ergometrine (increased plasma concentrations of these drugs).
– Reduce total daily dose to one third and give once daily to patients with severe hepatic impairment.
– Pregnancy: no contra-indication; divide into smaller doses, avoid prolonged use.
– Breast-feeding: significantly excreted in milk (risk of gastrointestinal disturbances in breastfed infants); divide into smaller doses, avoid prolonged use.


  Storage: below 25 °C - 
For the oral suspension: follow manufacturer’s instructions.