NICLOSAMIDE oral


Therapeutic action

– Anthelminthic (taenicide)

Indications

– Taeniasis: beef tapeworm (Taenia saginata), pork tapeworm (Taenia solium), dwarf tapeworm (Hymenolepis nana) and fish tapeworm (Diphyllobothrium latum)

Forms and strengths

– 500 mg chewable tablet

Dosage and duration

– T. saginata, T. solium and D. latum
Child under 2 years: 500 mg single dose
Child from 2 to 6 years: 1 g single dose
Child over 6 years and adult: 2 g single dose

– H. nana
Child under 2 years: 500 mg on D1, then 250 mg once daily for 6 days
Child from 2 to 6 years: 1 g on D1, then 500 mg once daily for 6 days
Child over 6 years and adult: 2 g on D1, then 1 g once daily for 6 days

Contra-indications, adverse effects, precautions

– May cause: gastrointestinal disturbances.
 Pregnancy: no contra-indication
– Breast-feeding: no contra-indication

Remarks

– Chew or crush the tablets before swallowing with water.
– In the event of vomiting, the single dose may be divided in 2 doses taken with an interval of one hour.
– As niclosamide is a taenicide not a taenifuge, do not expect the patient to expel the worm, portions are voided in a partially digested form.
– Niclosamide is not active against the larval form of T. solium (cysticercosis).
– Storage: below 25 °C -