PHENOXYMETHYLPENICILLIN = PENICILLIN V oral

Last updated: November 2021

Prescription under medical supervision


Therapeutic action

– Penicillin antibacterial

Indications

– Streptococcal pharyngitis, scarlet fever
– Alternative to first-line antibiotic treatment of diphtheria
– Completion treatment following parenteral therapy with penicillin

Forms and strengths

– 250 mg tablet (400 000 IU)
– Powder for oral suspension, 125 mg/5 ml (200 000 IU/5 ml), to be reconstituted with filtered water

Dosage

– Streptococcal pharyngitis, scarlet fever
Child under 1 year: 125 mg 2 times daily
Child 1 to < 6 years: 250 mg 2 times daily
Child 6 to < 12 years: 500 mg 2 times daily
Child 12 years and over and adult: 1 g 2 times daily

Age

Weight

125 mg/5 ml oral susp.

250 mg tablet

< 1 year

< 10 kg

1 tsp x 2

1 to < 6 years

10 to < 21 kg

2 tsp x 2

6 to < 12 years

21 to < 39 kg

4 tsp x 2

2 tab x 2

≥ 12 years and adult

≥ 39 kg

4 tab x 2

– Diphtheria
Child under 40 kg: 10 to 15 mg/kg (max. 500 mg) 4 times daily
Child 40 kg and over and adult: 500 mg 4 times daily

Duration

Streptococcal pharyngitis, scarlet fever: 10 days; diphtheria: 14 days.

Contra-indications, adverse effects, precautions

– Do not administer to patients with allergy to penicillin.
– Administer with caution to patients with allergy to cephalosporin (cross-sensitivity may occur) or severe renal impairment (reduce dose).
– May cause: diarrhea, nausea; allergic reactions sometimes severe.
– Do not combine with methotrexate.
Pregnancy: no contra-indication
Breast-feeding: no contra-indication

Remarks

– Take between meals.
– Phenoxymethylpenicillin is also used in children for the prevention of pneumococcal infections in sickle cell disease and recurrence of acute rheumatic fever.
Storage: below 25 °C - 
For the oral suspension (powder or reconstituted suspension): follow manufacturer’s instructions.