PRAZIQUANTEL oral

Prescription under medical supervision


Therapeutic action

– Anthelminthic

Indications

– Urinary (S. haematobium) and intestinal (S. mansoni, S. japonicum, S. mekongi, S. intercalatum) schistosomiasis
– Taeniasis (T. saginata, T. solium, D. latum, H. nana)
– Pulmonary (P. westermani), hepatobiliary (O. felineus, O. viverrini, C. sinensis) and intestinal (F. buski, H. heterophyes, M. yokogawai) flukes

Forms and strengths

– 600 mg breakable tablet

Dosage and duration

Child 4 years and over and adult:

Schistosomiasis
S. haematobium, S. mansoni, S. intercalatum: 40 mg/kg single dose or 2 doses of 20 mg/kg administered 4 hours apart
S. japonicum, S. mekongi: 2 doses of 30 mg/kg or 3 doses of 20 mg/kg administered 4 hours apart

Taeniase
T. saginata, T. solium, D. latum: 5 to 10 mg/kg single dose
H. nana: 15 to 25 mg/kg single dose

Fluke infections
• lung and hepatobiliary: 25 mg/kg 3 times daily for 2 days
• intestinal: 25 mg/kg 3 times daily, 1 day

Contra-indications, adverse effects, precautions

– Do not administer to patients with ocular cysticercosis.
– May cause:
• drowsiness, headache, gastrointestinal disturbances, dizziness; rarely: allergic reactions;
• neurological disorders (headache, seizures) in patients with undiagnosed neuro cysticercosis.
Pregnancy: no contra-indication for the treatment of schistosomiasis and taeniasis. If immediate treatment not considered essential for fluke infections, it should be delayed until after delivery.
Breast-feeding: no contra-indication

Remarks

– Do not chew the tablets due to their bitter taste. Take during meals.
– Praziquantel is not active against certain liver flukes (Fasciola hepatica and gigantica). For this indication, use triclabendazole.
Storage: below 30 °C