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Therapeutic action
- First-generation cephalosporin antibacterial
Indications
- Skin infections due to staphylococci and/or streptococci: impetigo, furuncle, erysipelas and superficial cellulitis
Forms and strengths
- 250 mg capsule
- 125 mg/5 ml powder for oral suspension
,:- to be reconstituted with filtered water
- to be administered using a measuring device (oral syringe, measuring spoon, or cup with graduations)
Dosage
- Neonate under 7 days: 25 mg/kg 2 times daily
- Neonate 7 to 28 days: 25 mg/kg 3 times daily
The exact dose should be calculated according to the newborn’s weight.
- Child 1 month to under 12 years: 12.5 to 25 mg/kg 2 times daily
- Child 12 years and over and adult: 1 g 2 times daily
|
Age |
Weight | Daily dose |
125 mg/5 ml oral susp. |
250 mg capsule |
|---|---|---|---|---|
|
1 to < 5 months |
4 to < 7 kg | 125 mg x 2 |
5 ml x 2 |
− |
|
5 months to < 3 years |
7 to < 15 kg | 187.5 mg x 2 |
7.5 ml x 2 |
− |
|
3 to < 6 years |
15 to < 20 kg | 250 mg x 2 |
10 ml x 2 |
– |
|
6 to < 12 years |
20 to < 40 kg | 500 mg x 2 |
– |
2 cap x 2 |
|
≥ 12 years and adult |
≥ 40 kg | 1 g x 2 |
– |
4 cap x 2 |
Duration
- Impetigo, furuncle: 7 days
- Erysipelas, cellulitis: 7 to 10 days
Contra-indications, adverse effects, precautions
- Do not administer to patients with allergy to cephalosporin.
- Administer with caution to patients with allergy to penicillin (cross-sensitivity may occur) and severe renal impairment (reduce the dose).
- May cause: gastrointestinal disturbances (particularly diarrhoea), allergic reactions (skin eruption, fever, pruritus).
- Pregnancy: no contra-indication
- Breast-feeding: no contra-indication
Remarks
- Take preferably between meals.
Storage
–
– Below 25 °C
For the oral suspension (powder or reconstituted suspension): follow manufacturer’s instructions.