CEFIXIME oral

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    Last updated: September 2022

     

    Prescription under medical supervision

     

    Therapeutic action

    • Third-generation cephalosporin antibacterial

    Indications

    • Typhoid fever
    • Acute cystitis in girls over 2 years, pregnant women and lactating women
    • Acute pyelonephritis in adults
    • Cervicitis and urethritis due to Neisseria gonorrhoeae (in combination with a treatment for chlamydia)
    • Second-line treatment of shigellosis

    Forms and strengths

    • 200 mg tablet
    • 100 mg/5 ml powder for oral suspension, to be reconstituted with filtered water

    Dosage

    Typhoid fever

    • Child: 10 mg/kg (max. 200 mg) 2 times daily
    • Adult: 200 mg 2 times daily

     

    Acute cystitis in girls over 2 years and shigellosis

    • Child: 8 mg/kg (max. 400 mg) once daily
    • Adult: 400 mg once daily

     

    Acute cystitis in pregnant and lactating women, acute pyelonephritis in adult

    • 200 mg 2 times daily

     

    Cervicitis and urethritis due to Neisseria gonorrhoeae

    • Child: 8 mg/kg (max. 400 mg) single dose
    • Adult: 400 mg single dose

    Duration

    • Typhoid fever and acute pyelonephritis: 10 to 14 days
    • Acute cystitis: 3 days for girls and 5 days for adults
    • Shigellosis: 5 days

    Contra-indications, adverse effects, precautions

    • Do not administer to patients with allergy to cephalosporins.
    • Administer with caution to penicillin-allergic patients (cross-sensitivity may occur) and in patients with severe renal impairment (reduce dosage).
    • May cause: gastrointestinal disturbances (especially diarrhoea), headache, dizziness, allergic reactions (rash, pruritus, fever). In the event of allergic reaction, stop treatment immediately.
    • Pregnancy: no contra-indication
    • Breast-feeding: no contra-indication

    Storage

     
    –  
     
    –  Below 25 °C 

    For the oral suspension (powder or reconstituted suspension): follow manufacturer’s instructions.