GRISEOFULVIN oral

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Prescription under medical supervision

 

Therapeutic action

  • Antifungal

Indications

  • Dermatophyte infections of the scalp (scalp ringworm)
  • Dermatophyte infections of the skin and folds, in the event of extended lesions or if the topical treatment has failed

Forms and strengths

  • 125 mg and 500 mg tablets

Dosage

  • Child 1 to 12 years: 10 to 20 mg/kg once daily (max. 500 mg daily)
  • Child 12 years and over and adult: 500 mg once daily; 1 g once daily in severe infections

 

Age

Weight

125 mg tablet

500 mg tablet

1 to < 2 years

10 to < 13 kg

1 tab

¼ tab

2 to < 7 years

13 to < 24 kg

2 tab

½ tab

7 to < 12 years

24 to < 35 kg

4 tab

1 tab

≥ 12 years and adult

≥ 35 kg

4 to 8 tab

1 to 2 tab

 

Duration

  • Scalp: 6 weeks minimum
  • Skin and folds: 4 to 6 weeks

Contra-indications, adverse effects, precautions

  • Do not administer to patients with hepatic impairment, lupus erythematous, porphyria (may trigger attacks of acute porphyria).
  • May cause: gastrointestinal disturbances, headache, skin reactions (eruption, urticaria, etc.); photosensitivity (protect exposed skin from sun exposure).
  • In women, use a non-hormonal contraception or injectable medroxyprogesterone during treatment and up to one month after the end of treatment.
  • Monitor patients taking warfarin (anticoagulant effect decreased).
  • Avoid alcohol during treatment (antabuse effect).
  • Pregnancy and breast-feeding: CONTRA-INDICATED. Apply a topical treatment (miconazole 2% cream or Whitfield ointment) in order to limit the lesions until it is possible to use griseofulvin.

Remarks

  • Take with meals.
  • For young children, crush the tablet and mix it with a liquid.

Storage

Below 25 °C