PYRIDOXINE = VITAMIN B6 oral

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    Therapeutic action

    • Vitamin

    Indications

    • Prevention and treatment of isoniazid-induced peripheral neuropathy

    Forms and strengths

    • 25 mg tablet

    Also comes in 10 mg and 50 mg tablets.

    Dosage

    Prevention of isoniazid neuropathy

    • Child under 5 kg: 5 mg once daily
    • Child over 5 kg and adult: 10 mg once daily

     

    Treatment of isoniazid neuropathy

    • Child: 50 mg once daily
    • Adult: 50 mg 3 times daily

    Duration

    • Prevention: as long as treatment with isoniazid continues.
    • Treatment: according to clinical response (in general, ≤ 3 weeks) then, preventive dose, as long as treatment with isoniazid continues.

    Contra-indications, adverse effects, precautions

    • No contra-indication.
    • May cause: peripheral neuropathy in the event of prolonged use with doses ≥ 200 mg daily.
    • Pregnancy: no contra-indication
    • Breast-feeding: no contra-indication

    Remarks

    • In children receiving isoniazid prophylaxis or treatment for tuberculosis: concomitant administration of pyridoxine at preventive dosage is recommended for children under 5 years and all children infected with HIV.
    • Pyridoxine is also used for the prevention and treatment of cycloserin-induced neuropathy (150 to 200 mg daily in adults, in divided doses).

    Storage

     
    –  Below 25 °C 
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