PYRIMETHAMINE oral

Select language:
Enter
Permalink
Download
Comment
Return to top
On this page

     

    Prescription under medical supervision


    Therapeutic action

    • Antiprotozoal

    Indications

    • Treatment and secondary prophylaxis of toxoplasmosis in immunodeficient patients, in combination with sulfadiazine or clindamycin
    • Primary prophylaxis of toxoplasmosis in immunodeficient patients, in combination with dapsone (only if co-trimoxazole cannot be used)
    • Second-line treatment of isosporiasis in immunodeficient patients (only if co-trimoxazole cannot be used)

    Forms and strengths

    •  25 mg tablet

    Dosage and duration

    Treatment of toxoplasmosis

    • Adult: 2 doses of 100 mg on D1, then 75 to 100 mg once daily for at least 6 weeks
       

    Secondary prophylaxis of toxoplasmosis

    • Adult: 25 to 50 mg once daily, as long as necessary
       

    Primary prophylaxis of toxoplasmosis

    • Adult: 50 to 75 mg once weekly, as long as necessary
       

    Treatment of isosporiasis

    • Adult: 50 to 75 mg once daily for 10 days

    Contra-indications, adverse effects, precautions

    • Do not administer to patients with severe renal or hepatic impairment.
    • May cause: gastrointestinal disturbances, seizures, leucopenia, thrombocytopenia, megaloblastic anaemia due to folic acid deficiency.
    • Administer calcium folinate to prevent folic acid deficiency.
    • Avoid if possible combination with other folate antagonists: co-trimoxazole, methotrexate (increased risk of folic acid deficiency).
    • Monitor combination with zidovudine (increased risk of zidovudine-associated haematotoxicity).
    • Pregnancy: CONTRA-INDICATED during the first trimester
    • Breast-feeding: no contra-indication; however avoid concomitant administration of other folate antagonists.

    Remarks

    • The combination of sulfadoxine/pyrimethamine is used for the treatment of uncomplicated falciparum malaria.

    Storage

    Below 25 °C

    Path