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Therapeutic action
- Antimalarial
Indications
- Treatment of uncomplicated falciparum malaria, when artemisinin-based combinations cannot be used
- Completion treatment following parenteral therapy with quinine for severe falciparum malaria, when artemisinin-based combinations cannot be used
Forms and strengths
- 300 mg quinine sulfate tablet
Dosage and duration
Dosage is expressed in terms of salt. Except for quinine bisulfate, the dosage is the same for all quinine salts (sulfate, hydrochloride, dihydrochloride):
- Child and adult < 50 kg: 10 mg/kg 3 times daily at 8-hour intervals for 7 days
- Adult ≥ 50 kg: 600 mg 3 times daily at 8-hour intervals for 7 days
|
Age |
Weight |
300 mg tablet |
|---|---|---|
|
5 months to < 2 years |
7 to < 12 kg |
¼ tab x 3 |
|
2 to < 8 years |
12 to < 25 kg |
½ tab x 3 |
|
8 to < 11 years |
25 to < 35 kg |
1 tab x 3 |
|
11 to < 14 years |
35 to < 50 kg |
1½ tab x 3 |
|
≥ 14 years |
≥ 50 kg |
2 tab x 3 |
Contra-indications, adverse effects, precautions
- May cause: headache, skin rash; visual, auditory and gastrointestinal disturbances.
- Do not exceed indicated doses: risk of toxicity in the event of overdose.
- Avoid combination with drugs that prolong QT interval: amiodarone, other antimalarials, antipsychotics, fluconazole, fluoroquinolones, hydroxyzine, macrolides, ondansetron, etc.
- If the patient vomits within 30 minutes after administration, re-administer the full dose. If the patient vomits between 30 minutes and 1 hour after administration, re-administer half of the dose.
- Pregnancy: no contra-indication; it is recommended to administer quinine in combination with clindamycin if possible.
- Breast-feeding: no contra-indication
Remarks
- 10 mg of quinine sulfate or hydrochloride or dihydrochloride = 8 mg of quinine base; 14 mg of quinine bisulfate = 8 mg of quinine base.
Storage
– Below 25 °C