AZITHROMYCIN oral

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    Last updated: January 2021

     

    Prescription under medical supervision

     

    Therapeutic action

    • Macrolide antibacterial

    Indications

    • Trachoma, conjunctivitis due to Chlamydia trachomatis
    • Cervicitis and urethritis due to Chlamydia trachomatis (in combination with a treatment for gonorrhoea), donovanosis, chancroid, early syphilis
    • Cholera (if the strain is susceptible), typhoid fever, yaws, leptospirosis
    • Pertussis, diphtheria, pneumonia due to Mycoplasma pneumoniae and Chlamydophila pneumoniae
    • Second-line treatment of shigellosis
    • Streptococcal tonsillitis, acute otitis media, in penicillin-allergic patients only

    Forms and strengths

    • 250 mg and 500 mg capsules or tablets
    • 200 mg/5 ml powder for oral suspension, to be reconstituted with filtered water

    Dosage and duration

    Trachoma, cholera, cervicitis and urethritis due to C. trachomatis, chancroid, early syphilis

    • Child: 20 mg/kg single dose (max. 1 g)
    • Adult: 1 g single dose (2 g single dose in early syphilis)

     

    Yaws

    • Child and adult: 30 mg/kg single dose (max. 2 g)

     

    Conjunctivitis due to C. trachomatis

    • Child: 20 mg/kg once daily for 3 days (max. 1 g daily)
    • Adult: 1 g once daily for 3 days

     

    Typhoid fever

    • Child: 10 to 20 mg/kg once daily for 7 days (max. 1 g daily)
    • Adult: 1 g once daily for 7 days

     

    Donovanosis (granuloma inguinale)

    • Adult: 1 g on D1 then 500 mg once daily until healing of lesions

     

    Pertussis, pneumonia due to M. pneumoniae and C. pneumoniae

    • Child: 10 mg/kg once daily for 5 days (max. 500 mg daily)
    • Adult: 500 mg on D1 then 250 mg once daily from D2 to D5

     

    Leptospirosis

    • Child: 10 mg/kg on D1 (max. 500 mg) then 5 mg/kg once daily on D2 and D3 (max. 250 mg daily)
    • Adult: 1 g on D1 then 500 mg once daily on D2 and D3 

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    Shigellosis

    • Child: 12 mg/kg on D1 then 6 mg/kg once daily from D2 to D5
    • Adult: 500 mg on D1 then 250 mg once daily from D2 to D5

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    Diphtheria

    • Child: 10 to 12 mg/kg once daily for 14 days (max. 500 mg daily)
    • Adult: 500 mg once daily for 14 days

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    Streptococcal tonsillitis, only in penicillin-allergic patients

    • Child: 20 mg/kg once daily for 3 days (max. 500 mg daily)
    • Adult: 500 mg once daily for 3 days

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    Acute otitis media, only in penicillin-allergic patients

    • Child: 10 mg/kg once daily for 3 days (max. 500 mg daily)

    Contra-indications, adverse effects, precautions

    • Do not administer to patients with allergy to azithromycin or another macrolide, and to patients with severe hepatic impairment.
    • May cause: gastrointestinal disturbances, heart rhythm disorders (QT prolongation), allergic reactions sometimes severe. In the event of allergic reaction, stop treatment immediately.
    • Do not administer simultaneously with antacids (aluminium or magnesium hydroxide, etc.). Administer 2 hours apart.
    • Avoid combination with drugs that prolong the QT interval (amiodarone, chloroquine, co-artemether, fluconazole, haloperidol, mefloquine, moxifloxacin, ondansetron, pentamidine, quinine, etc.).
    • Administer with caution and monitor use in patients taking digoxin (increased digoxin plasma levels).
    • Pregnancy and breast-feeding: no contra-indication

    Remarks

    • Also comes in 250 mg or 500 mg capsules, to be taken one hour before or 2 hours after a meal.​​​​​​​

    Storage

     
    -
     
    - Below 25 °C 

    For the oral suspension (powder or reconstituted suspension): follow manufacturer’s instructions.