CEFIXIME oral

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    Prescription under medical supervision

     

    Therapeutic action

    • Third-generation cephalosporin antibacterial

    Indications

    • Typhoid fever
    • Acute cystitis in girls over 2 years, pregnant women and lactating women
    • Acute pyelonephritis in adults
    • Cervicitis and urethritis due to Neisseria gonorrhoeae (in combination with a treatment for chlamydia)

    Forms and strengths

    • 200 mg tablet
    • 100 mg/5 ml powder for oral suspension, to be reconstituted with filtered water

    Dosage

    Typhoid fever

    • Child: 10 mg/kg 2 times daily (max. 400 mg daily)
    • Adult: 200 mg 2 times daily

     

    Acute cystitis in girls over 2 years

    • 8 mg/kg once daily

     

    Acute cystitis in pregnant and lactating women, acute pyelonephritis in adult

    • 200 mg 2 times daily

     

    Cervicitis and urethritis due to Neisseria gonorrhoeae

    • Child: 8 mg/kg single dose
    • Adult: 400 mg single dose

    Duration

    • Typhoid fever: 7 days
    • Acute cystitis: 3 days for girls and 5 days for adults
    • Acute pyelonephritis: 10 to 14 days

    Contra-indications, adverse effects, precautions

    • Do not administer to patients with allergy to cephalosporins.
    • Administer with caution to penicillin-allergic patients (cross-sensitivity may occur) and in patients with severe renal impairment (reduce dosage).
    • May cause: gastrointestinal disturbances (especially diarrhoea), headache, dizziness, allergic reactions (rash, pruritus, fever). In the event of allergic reaction, stop treatment immediately.
    • Pregnancy: no contra-indication
    • Breast-feeding: no contra-indication

    Remarks

    • Cefixime is also used in the second-line treatment of shigellosis (child: 8 mg/kg once daily; adult: 400 mg once daily) for 5 days.
    • Also comes in 400 mg capsules.

    Storage

     
    -
     
    - Below 25 °C 

    For the oral suspension (powder or reconstituted suspension): follow manufacturer’s instructions.