CALCIUM FOLINATE = FOLINIC acid oral

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    Prescription under medical supervision

    Therapeutic action

    • Antidote to folate antagonists

    Indications

    • Prevention of haemotological toxicity of pyrimethamine when pyrimethamine is used as prophylaxis for, or in the treatment of toxoplasmosis or isosporiasis in immunodeficient patients

    Forms and strengths

    • 15 mg tablet

    Also comes in 5 mg and 25 mg capsules.

    Dosage

    When pyrimethamine is used as primary or secondary prophylaxis for toxoplasmosis

    • Adult: 25 to 30 mg once weekly

    During treatment of toxoplasmosis

    • Adult: 10 to 25 mg once daily

    During treatment of isosporiasis

    • Adult: 5 to 15 mg once daily

    Duration

    • For the duration of the pyrimethamine treatment

    Contra-indications, adverse effects, precautions

    • Pregnancy: NO CONTRA-INDICATION
    • Breast-feeding: NO CONTRA-INDICATION

    Remarks

    • Folic acid cannot be used as an alternative to folinic acid for the treatment of toxoplasmosis: folic acid reduces the antiprotozoal activity of pyrimethamine.
    • Calcium folinate is also called calcium leucovorin.


    Storage

     
     - below 25 °C 
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