GRISEOFULVIN oral

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    Prescription under medical supervision

     

    Therapeutic action

    • Antifungal

    Indications

    • Dermatophyte infections of the scalp (scalp ringworm)
    • Dermatophyte infections of the skin and folds, in the event of extended lesions or if the topical treatment has failed

    Forms and strengths

    • 125 mg and 500 mg tablets

    Dosage

    • Child 1 to 12 years: 10 to 20 mg/kg once daily (max. 500 mg daily)
    • Child 12 years and over and adult: 500 mg once daily; 1 g once daily in severe infections

     

    Age

    Weight

    125 mg tablet

    500 mg tablet

    1 to < 2 years

    10 to < 13 kg

    1 tab

    ¼ tab

    2 to < 7 years

    13 to < 24 kg

    2 tab

    ½ tab

    7 to < 12 years

    24 to < 35 kg

    4 tab

    1 tab

    ≥ 12 years and adult

    ≥ 35 kg

    4 to 8 tab

    1 to 2 tab

     

    Duration

    • Scalp: 6 weeks minimum
    • Skin and folds: 4 to 6 weeks

    Contra-indications, adverse effects, precautions

    • Do not administer to patients with hepatic impairment, lupus erythematous, porphyria (may trigger attacks of acute porphyria).
    • May cause: gastrointestinal disturbances, headache, skin reactions (eruption, urticaria, etc.); photosensitivity (protect exposed skin from sun exposure).
    • In women, use a non-hormonal contraception or injectable medroxyprogesterone during treatment and up to one month after the end of treatment.
    • Monitor patients taking warfarin (anticoagulant effect decreased).
    • Avoid alcohol during treatment (antabuse effect).
    • Pregnancy and breast-feeding: CONTRA-INDICATED. Apply a topical treatment (miconazole 2% cream or Whitfield ointment) in order to limit the lesions until it is possible to use griseofulvin.

    Remarks

    • Take with meals.
    • For young children, crush the tablet and mix it with a liquid.

    Storage

    Below 25 °C