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Therapeutic action
- Antifungal
Indications
- Dermatophyte infections of the scalp (scalp ringworm)
- Dermatophyte infections of the skin and folds, in the event of extended lesions or if the topical treatment has failed
Forms and strengths
- 125 mg and 500 mg tablets
Dosage
- Child 1 to 12 years: 10 to 20 mg/kg once daily (max. 500 mg daily)
- Child 12 years and over and adult: 500 mg once daily; 1 g once daily in severe infections
|
Age |
Weight |
125 mg tablet |
500 mg tablet |
|---|---|---|---|
|
1 to < 2 years |
10 to < 13 kg |
1 tab |
¼ tab |
|
2 to < 7 years |
13 to < 24 kg |
2 tab |
½ tab |
|
7 to < 12 years |
24 to < 35 kg |
4 tab |
1 tab |
|
≥ 12 years and adult |
≥ 35 kg |
4 to 8 tab |
1 to 2 tab |
Duration
- Scalp: 6 weeks minimum
- Skin and folds: 4 to 6 weeks
Contra-indications, adverse effects, precautions
- Do not administer to patients with hepatic impairment, lupus erythematous, porphyria (may trigger attacks of acute porphyria).
- May cause: gastrointestinal disturbances, headache, skin reactions (eruption, urticaria, etc.); photosensitivity (protect exposed skin from sun exposure).
- In women, use a non-hormonal contraception or injectable medroxyprogesterone during treatment and up to one month after the end of treatment.
- Monitor patients taking warfarin (anticoagulant effect decreased).
- Avoid alcohol during treatment (antabuse effect).
- Pregnancy and breast-feeding: CONTRA-INDICATED. Apply a topical treatment (miconazole 2% cream or Whitfield ointment) in order to limit the lesions until it is possible to use griseofulvin.
Remarks
- Take with meals.
- For young children, crush the tablet and mix it with a liquid.
Storage
Below 25 °C