AMOXICILLIN oral

Prescription under medical supervision


Therapeutic action

– Penicillin antibacterial

Indications

– Acute otitis media, streptococcal tonsillitis, sinusitis, bronchitis, pneumonia
– Infection due to Helicobacter pylori (in combination with omeprazole and clarithromycin), leptospirosis, uncomplicated cutaneous anthrax
– Typhoid fever if the strain is susceptible (recent drug susceptibility test)
– Completion treatment following parenteral therapy with penicillins or cephalosporins

Forms and strengths

– 250 mg and 500 mg tablets or capsules
– 250 mg dispersible scored tablet, for paediatric use
– 125 mg/5 ml powder for oral suspension, to be reconstituted with filtered water

Dosage

Usual dosage (e.g. leptospirosis, tonsillitis, infection due to H. pylori)
Child: 25 mg/kg 2 times daily 
Adult: 1 g 2 times daily

Age

Weight

125 mg/5 ml susp.

250 mg tablet

500 mg tablet

< 3 months

< 6 kg

1 tsp x 2

½ tab x 2

3 to < 24 months

6 to < 12 kg

2 tsp x 2

1 tab x 2

2 to < 8 years

12 to < 25 kg

4 tsp x 2

2 tab x 2

1 tab x 2

≥ 8 years and adult

≥ 25 kg

4 tab x 2

2 tab x 2

Severe infections (e.g. typhoid fever) or suspicion of resistant pneumococci (e.g. pneumonia, otitis)
Child: 30 mg/kg 3 times daily (max. 3 g daily)
Adult: 1 g 3 times daily

Age

Weight

125 mg/5 ml susp.

250 mg tablet

500 mg tablet

< 3 months

< 6 kg

1 tsp x 3

½ tab x 3

3 to < 24 months

6 to < 12 kg

2 tsp x 3

1 tab x 3

2 to < 8 years

12 to < 25 kg

4 tsp x 3

2 tab x 3

1 tab x 3

≥ 8 years and adult

≥ 25 kg

4 tab x 3

2 tab x 3

Duration

Otitis media: 5 days; tonsillitis: 6 days; leptospirosis, typhoid fever: 7 days; pneumonia, sinusitis, cutaneous anthrax: 7 to 10 days; H. pylori infection: 7 days

Contra-indications, adverse effects, precautions

– Do not administer to penicillin-allergic patients or patients with mononucleosis.
– Administer with caution to patients allergic to cephalosporins (cross-sensitivity may occur).
– May cause: gastrointestinal disturbances, allergic reactions, sometimes severe. In the event of allergic reaction, stop treatment immediately.
– Reduce dosage in patients with severe renal impairment.
– Do not combine with methotrexate.
Pregnancy and breast-feeding: no contra-indication

Remarks

  Storage: below 25 °C -  - 
For the oral suspension (powder or reconstituted suspension): follow manufacturer’s instructions.