GRISEOFULVIN oral

Prescription under medical supervision


Therapeutic action

– Antifungal

Indications

– Dermatophyte infections of the scalp (scalp ringworm)
– Dermatophyte infections of the skin and folds, in the event of extended lesions or if the topical treatment has failed

Forms and strengths

– 125 mg and 500 mg tablets

Dosage

– Child 1 to 12 years: 10 to 20 mg/kg once daily (max. 500 mg daily)
– Child 12 years and over and adult: 500 mg once daily; 1 g once daily in severe infections

Age

Weight

125 mg tablet

500 mg tablet

1 to < 2 years

10 to < 13 kg

1 tab

¼ tab

2 to < 7 years

13 to < 24 kg

2 tab

½ tab

7 to < 12 years

24 to < 35 kg

4 tab

1 tab

≥ 12 years and adult

≥ 35 kg

4 to 8 tab

1 to 2 tab

Duration

– Scalp: 6 weeks minimum
– Skin and folds: 4 to 6 weeks

Contra-indications, adverse effects, precautions

– Do not administer to patients with hepatic impairment, lupus erythematous, porphyria (may trigger attacks of acute porphyria).
– May cause: gastrointestinal disturbances, headache, skin reactions (eruption, urticaria, etc.); photosensitivity (protect exposed skin from sun exposure).
– In women, use a non-hormonal contraception or injectable medroxyprogesterone during treatment and up to one month after the end of treatment.
– Monitor patients taking warfarin (anticoagulant effect decreased).
– Avoid alcohol during treatment (antabuse effect).
 Pregnancy and breast-feedingCONTRA-INDICATED. Apply a topical treatment (miconazole 2% cream or Whitfield ointment) in order to limit the lesions until it is possible to use griseofulvin.

Remarks

– Take with meals.
– For young children, crush the tablet and mix it with a liquid.
 Storage: below 25 °C