QUININE oral

Prescription under medical supervision


Therapeutic action

– Antimalarial

Indications

– Treatment of uncomplicated falciparum malaria, when artemisinin-based combinations cannot be used
– Completion treatment following parenteral therapy with quinine for severe falciparum malaria, when artemisinin-based combinations cannot be used

Forms and strengths

– 300 mg quinine sulfate tablet

Dosage and duration

Dosage is expressed in terms of salt. Except for quinine bisulfate, the dosage is the same for all quinine salts (sulfate, hydrochloride, dihydrochloride):
– Child and adult < 50 kg: 10 mg/kg 3 times daily at 8-hour intervals for 7 days
– Adult ≥ 50 kg: 600 mg 3 times daily at 8-hour intervals for 7 days

Age

Weight

300 mg tablet

5 months to < 2 years

7 to < 12 kg

¼ tab x 3

2 to < 8 years

12 to < 25 kg

½ tab x 3

8 to < 11 years

25 to < 35 kg

1 tab x 3

11 to < 14 years

35 to < 50 kg

1½ tab x 3

≥ 14 years

≥ 50 kg

2 tab x 3

Contra-indications, adverse effects, precautions

May cause: headache, skin rash; visual, auditory and gastrointestinal disturbances.
– Do not exceed indicated doses: risk of toxicity in the event of overdose.
– Avoid combination with drugs that prolong QT interval: amiodarone, other antimalarials, antipsychotics, fluconazole, fluoroquinolones, hydroxyzine, macrolides, ondansetron, etc.
– If the patient vomits within 30 minutes after administration, re-administer the full dose. If the patient vomits between 30 minutes and 1 hour after administration, re-administer half of the dose.

Pregnancy: no contra-indication; it is recommended to administer quinine in combination with clindamycin if possible.
Breast-feeding: no contra-indication

Remarks

– 10 mg of quinine sulfate or hydrochloride or dihydrochloride = 8 mg of quinine base; 14 mg of quinine bisulfate = 8 mg of quinine base.
Storage: below 25 °C