Last updated: September 2021
– Antituberculosis antibacterial (bactericidal activity)
– Latent tuberculosis, in combination with isoniazid
Forms and strengths
– 150 mg tablet
Dosage and duration
– Weekly regimen for 3 months, in combination with isoniazid
Child 2 years and over and adult:
150 mg tablet
10 to 14 kg
2 tab once weekly
14.1 to 25 kg
3 tab once weekly
25.1 to 32 kg
4 tab once weekly
32.1 to 49.0 kg
5 tab once weekly
≥ 50 kg
6 tab once weekly
– Daily regimen for 1 month, in combination with isoniazid
Child 13 years and over and adult: 600 mg once daily
Contra-indications, adverse effects, precautions
– Do not administer to patients with jaundice, hypersensitivity to rifamycins or history of severe haematological disorders (thrombocytopenia, purpura) during a previous treatment with rifamycins.
– Do not administer the weekly regimen to children under 2 years or the daily regimen to children under 13 years.
– Avoid or administer with caution to patients with hepatic disorders.
– May cause:
• harmless orange-red discoloration of body secretions (urine, tears, saliva, sputum, sweat, etc.);
• gastrointestinal disturbances; rarely, hepatotoxicity;
• headache, influenza-like symptoms;
• haematological disorders, cutaneous reactions (rash, pruritus) and hypersensitivity reactions (approximately 4% of patients).
– If signs of hepatotoxicity develop (e.g. jaundice), rifapentine should be discontinued until symptoms resolve.
– Rifapentine reduces the effect of many drugs (antimicrobials, anticonvulsants, some antiretrovirals, some hormones, antidiabetics, corticosteroids, direct-acting antivirals for chronic hepatitis C, warfarin, etc.):
• do not administer in patients on protease inhibitors or nevirapine;
• in women using contraceptive, use medroxyprogesterone or an intrauterine device;
• in the event of concomitant fluconazole administration, administer each drug 12 hours apart (rifapentine in the morning, fluconazole in the evening);
• for the other drugs, adjust dosage if necessary.
– Pregnancy and breast-feeding: not recommended (safety not established)
– Tablets can be crushed and mixed into a spoon with a small amount of food.
– Also comes in fixed dose combination containing 300 mg of rifapentine/300 mg of isoniazid. Prefer this formulation for weekly regimens to reduce the pill burden (3 tablets once weekly). This formulation is only recommended for children over 14 years and adults.
– Rifapentine and rifampicin are not interchangeable in regimens for latent tuberculosis.
– Storage: below 25 °C - -