RIFAPENTINE = P oral

Last updated: September 2021

Prescription under medical supervision


Therapeutic action

– Antituberculosis antibacterial (bactericidal activity) 

Indications

 – Latent tuberculosis, in combination with isoniazid  

Forms and strengths

– 150 mg tablet  

Dosage and duration

– Weekly regimen for 3 months, in combination with isoniazid  
Child 2 years and over and adult: 

Weight

Weekly dosage

150 mg tablet

10 to 14 kg 

300 mg 

2 tab once weekly 

14.1 to 25 kg 

450 mg 

3 tab once weekly 

25.1 to 32 kg 

600 mg 

4 tab once weekly 

32.1 to 49.0 kg 

750 mg 

5 tab once weekly 

≥ 50 kg 

900 mg 

6 tab once weekly 

– Daily regimen for 1 month, in combination with isoniazid 
Child 13 years and over and adult: 600 mg once daily 

Contra-indications, adverse effects, precautions

– Do not administer to patients with jaundice, hypersensitivity to rifamycins or history of severe haematological disorders (thrombocytopenia, purpura) during a previous treatment with rifamycins. 
– Do not administer the weekly regimen to children under 2 years or the daily regimen to children under 13 years. 
– Avoid or administer with caution to patients with hepatic disorders. 
– May cause: 
• harmless orange-red discoloration of body secretions (urine, tears, saliva, sputum, sweat, etc.); 
• gastrointestinal disturbances; rarely, hepatotoxicity; 
• headache, influenza-like symptoms; 
• haematological disorders, cutaneous reactions (rash, pruritus) and hypersensitivity reactions (approximately 4% of patients).
– If signs of hepatotoxicity develop (e.g. jaundice), rifapentine should be discontinued until symptoms resolve. 
– Rifapentine reduces the effect of many drugs (antimicrobials, anticonvulsants, some antiretrovirals, some hormones, antidiabetics, corticosteroids, direct-acting antivirals for chronic hepatitis C, warfarin, etc.): 
• do not administer in patients on protease inhibitors or nevirapine; 
• in women using contraceptive, use medroxyprogesterone or an intrauterine device; 
• in the event of concomitant fluconazole administration, administer each drug 12 hours apart (rifapentine in the morning, fluconazole in the evening); 
• for the other drugs, adjust dosage if necessary. 
– Pregnancy and breast-feeding: not recommended (safety not established) 

Remarks

– Tablets can be crushed and mixed into a spoon with a small amount of food. 
– Also comes in fixed dose combination containing 300 mg of rifapentine/300 mg of isoniazid. Prefer this formulation for weekly regimens to reduce the pill burden (3 tablets once weekly). This formulation is only recommended for children over 14 years and adults.  
– Rifapentine and rifampicin are not interchangeable in regimens for latent tuberculosis. 
Storage: below 25 °C -  -