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    Prescription under medical supervision


    Therapeutic action

    • Sulfonylurea antidiabetic  


    • Second-line treatment of type 2 diabetes, in patients under 60 years:
      • as monotherapy, when metformin is not tolerated or contra-indicated
      • in combination with metformin, when glycaemic control is inadequate with metformin alone

    Forms and strengths

    • 5 mg scored tablet

    Dosage and duration

    • Adult:

    Week 1: 2.5 mg once daily in the morning
    Week 2: 5 mg once daily in the morning
    Increase if necessary in increments of 2.5 mg weekly, according to blood glucose levels.
    The usual dose is 5 mg 2 times daily (max. 15 mg daily).

    Contra-indications, adverse effects, precautions

    • Do not administer in the event of:
      • allergy to sulfonamides;
      • type 1 diabetes, juvenile diabetes, ketoacidosis;
      • severe renal or hepatic impairment.
    • May cause: hypoglycaemia, especially in patients over 60 years; gastrointestinal disturbances, weight gain; rarely, allergic reactions.
    • Monitor combination with:
      • diuretics, angiotensin-converting enzyme inhibitors, non-steroidal anti-inflammatory drugs, azole antifungals (fluconazole, miconazole), ciprofloxacin, erythromycin, co-trimoxazole (enhanced hypoglycaemic effect);
      • rifampicin (decreased hypoglycaemic effect);
      • drugs increasing blood glucose levels: corticosteroids, hydrochlorothiazide, salbutamol, chlorpromazine.
    • Avoid combination with alcohol (antabuse reaction and risk of hypoglycaemia).
    • Pregnancy: avoid. Insulin is the drug of choice for the treatment of type 2 diabetes in pregnant women (improved glycaemic control; reduced risk of foetal anomalies and neonatal complications).
    • Breast-feeding: CONTRA-INDICATED


    • Take with meals.
    • For doses greater than 5 mg/day, divide the daily dose into 2 doses.


    - Below 25 °C